干细胞移植治疗糖尿病及其并发症, 4.6亿患者的福音!

2021-08-11 16:30 来源: 人民资讯

糖尿病并发症对糖尿病患者的寿命和生活质量造成了很大的影响,干细胞移植改善糖尿病患者的代谢控制和β细胞功能,随着干细胞技术的发展,给糖尿病及其并发症的治疗带来了新希望,

参考资料

【1】:Malmegrim KC,de Azevedo JT,Arruda LC,et a1.Immunologi— cal balance is associated with clinical outcome after autologous hematopoietic stem cell transplantation in type 1 diabetes. Front Immunol,2017,8:167.

【2】:Skyler JS,Fonseca VA,Segal KR,et a1.Allogeneic mesenchy— mal precursor cells in type 2 diabetes:A randomized,placebocontrolled,dose-escalation safe/y and tolerability pilot study. Diabetes Care,2015,38:1742—1749.

【3】:Lv S,Cheng J,Sun A,et a1.Mesenehymal stem cells transplan— tation ameliorates glomerular injury in streptozotocin-induced diabetic nephropathy in rats via inhibiting oxidative stress.Dia— betes Res C1in Pract,2014,104:143—154.

【4】:Lv S,Liu G,Sun A,et a1.Mesenchymal stem cells ameliorate diabetic glomerular fibrosis in vivo and in vitro by inhibiting TGF-beta signalling via secretion of bone morphogenetic pro— tein 7.Diab Vase Dis Ras,2014,1l:251—261.

【5】:Lupachyk S,Shevalye H,Maksimchyk Y,et a1.PARP inhibi— tion alleviates diabetes—indueed systemic oxidative stress and neural tissue 4-hydroxynonenal adduct accumulation:correla— tion with peripheral nerve function.Free Radic Biol Med, 2011,50:1400—1409.

【6】:Khan M,Ali F,Mohsin S,et a1.Preconditioning diabetic mesen— chymal stem cells with myogenic medium increases their ability to repair diabetic heart.Stem Cell Res Ther,2013,4:58.

来源:健康界

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